Peer-reviewed veterinary case report
Persistent high reticulocyte count in poodle macrocytosis case
By Boyd, Susan P & Best, Matthew PĀ·Published in Veterinary clinical pathologyĀ·2018Ā·QML Vetnostics, AustraliaĀ·View original on PubMed ā
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Original publication title: Persistent reticulocytosis in a case of poodle macrocytosis.
- Species:
- dog
Plain-English summary
A 14-year-old male Miniature Poodle was found to have an unusual blood condition called macrocytosis, which means his red blood cells were larger than normal. Despite this, he did not show signs of anemia or other blood issues. The vet noted some specific changes in his bone marrow that are linked to a genetic condition known as poodle macrocytosis. While the dog appeared healthy, the persistent increase in young red blood cells (reticulocytosis) raised questions about whether this was a variation of the inherited condition. The dog remained stable without any specific treatment needed.
People also search for: Miniature Poodle blood condition Ā· dog macrocytosis symptoms Ā· poodle reticulocytosis treatment
Abstract
A healthy 14-year-old, male neutered, Miniature Poodle was found to have a persistent erythrocyte macrocytosis and reticulocytosis with a normal and stable HCT. The hematologic features of macrocytosis, increased Howell-Jolly bodies, and metarubricytosis, in the absence of anemia or other cytopenias, combined with the cytologic evidence of bone marrow erythroid dysplasia, including megaloblastosis, binuclearity, increased mitotic activity, and nuclear fragmentation, are consistent with previous reports of congenital dyserythropoiesis termed poodle macrocytosis. We speculate that the additional presence of persistent reticulocytosis in the absence of an identifiable stimulus for accelerated erythropoiesis may represent a phenotypic variation of this inherited condition, and the morphologic abnormalities of the dyserythropoiesis are described.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29947425/