Peer-reviewed veterinary case report
Perspectives on pharmacologic strategies in the management of meningoencephalomyelitis of unknown origin in dogs.
- Journal:
- Frontiers in veterinary science
- Year:
- 2023
- Authors:
- Beasley, Michaela J & Shores, Andy
- Affiliation:
- College of Veterinary Medicine · United States
- Species:
- dog
Plain-English summary
There are several non-infectious inflammatory diseases that can affect a dog's nervous system, and one of these is called meningoencephalomyelitis of unknown origin. This condition is thought to be caused by the immune system attacking the body. To treat it, veterinarians often use a combination of steroids and other medications like Cytosar or cyclosporine. The steroids are usually given at first and then gradually reduced, while the other medication helps manage the condition over the long term. The exact timing for reducing the steroids can vary from one veterinarian to another, as there isn't a set guideline for this. Additionally, dogs may need supportive treatments during the initial phase of their illness, such as medications to reduce swelling or prevent seizures. Overall, the treatment approach has been shown to be effective in managing this condition.
Abstract
There are many non-infectious inflammatory diseases, assumed to be immune-mediated in origin, recognized to affect the nervous system in canine patients. Concentrating on meningoencephalomyelitis of unknown origin, we will discuss the medications used to treat the underlying disease process, focusing on their adverse effects, therapeutic monitoring when necessary and effectiveness. The literature overwhelmingly supports the use of a steroid/ Cytosaror steroid/ cyclosporine treatment protocol with the steroid tapered after the acute phase of the disease, leaving the secondary medication to control the disease long term. The decision on when and how quickly to taper the steroid is clinician dependent as a best practices has not been established in the literature. Also discussed will be the supportive care treatments often needed in the acute phase of these patients' diagnosis and treatment such as anti-edema and anti-epileptic agents.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37234070/