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Peer-reviewed veterinary case report

Drug treatments for meningoencephalomyelitis of unknown origin in dogs

By Beasley, Michaela J & Shores, Andy·Published in Frontiers in veterinary science·2023·College of Veterinary Medicine, United States·View original on PubMed

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Original publication title: Perspectives on pharmacologic strategies in the management of meningoencephalomyelitis of unknown origin in dogs.

Species:
dog

Plain-English summary

A dog with an unknown cause of brain inflammation, known as meningoencephalomyelitis, was treated with a combination of steroids and other medications to manage the condition. The treatment plan involved starting with steroids to reduce inflammation and then tapering them off while continuing with other medications like Cytosar or cyclosporine for long-term control. Supportive care, including medications to reduce swelling and prevent seizures, was also provided during the initial treatment phase. This approach has been shown to be effective in managing the symptoms and improving the dog's condition over time.

People also search for: dog brain inflammation treatment · meningoencephalomyelitis in dogs · dog seizure prevention medication

Abstract

There are many non-infectious inflammatory diseases, assumed to be immune-mediated in origin, recognized to affect the nervous system in canine patients. Concentrating on meningoencephalomyelitis of unknown origin, we will discuss the medications used to treat the underlying disease process, focusing on their adverse effects, therapeutic monitoring when necessary and effectiveness. The literature overwhelmingly supports the use of a steroid/ Cytosaror steroid/ cyclosporine treatment protocol with the steroid tapered after the acute phase of the disease, leaving the secondary medication to control the disease long term. The decision on when and how quickly to taper the steroid is clinician dependent as a best practices has not been established in the literature. Also discussed will be the supportive care treatments often needed in the acute phase of these patients' diagnosis and treatment such as anti-edema and anti-epileptic agents.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37234070/