Peer-reviewed veterinary case report
Dog diagnosed with rare phagocytic plasmacytoma tumor
By Yearley, Jennifer H et al.·Published in Veterinary clinical pathology·2007·Department of Molecular Biomedical Sciences, United States·View original on PubMed →
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Original publication title: Phagocytic plasmacytoma in a dog.
- Species:
- dog
Plain-English summary
A 4-year-old neutered male Golden Retriever was brought to the veterinary oncology department because of a tumor on his left front leg. After examining the dog and performing tests, the veterinarians found that he had a type of cancer called a phagocytic plasmacytoma, which is a tumor made up of abnormal plasma cells. The tumor was removed through amputation of the leg, and further tests confirmed the nature of the tumor. While the prognosis can vary, treatment options for similar cases often include surgery and possibly chemotherapy, depending on the specific situation.
People also search for: Golden Retriever cancer treatment · dog tumor leg amputation · phagocytic plasmacytoma in dogs
Abstract
A 4-year-old neutered male Golden Retriever was presented to the oncology service of the North Carolina State University Veterinary Teaching Hospital for staging of a histiocytic sarcoma of the left forelimb, diagnosed on the basis of biopsies submitted by the referring veterinarian. Cytologic assessment of aspirates of 2 splenic nodules identified on ultrasonographic examination of the abdomen revealed a highly phagocytic population of neoplastic round cells morphologically suggestive of plasma cells. Histologic assessment of the forelimb mass after amputation of the limb revealed a neoplastic round cell population demonstrating extensive cytophagia and erythrophagia. Immunohistochemical analysis of the tumor population revealed it to be negative for BLA.36 with sporadic positivity for lysozyme and CD79a. Immunofluorescent evaluation revealed weak tumor cell positivity for immunoglobulin (Ig) A and IgM, but extensive strong positivity for IgG, confirming the plasma cell origin of the tumor. Although extensive phagocytic activity may strongly suggest histiocytic origin, plasma cell origin must also be considered among the differential diagnoses for phagocytic round cell tumors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17806081/