Peer-reviewed veterinary case report
Pharmacodynamics of Omadacycline against Staphylococcus aureus in the Neutropenic Murine Thigh Infection Model.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2019
- Authors:
- Lepak, Alexander J et al.
- Affiliation:
- Department of Medicine · United States
Abstract
Omadacycline is a novel aminomethylcycline antibiotic with potent activity against, including methicillin-susceptible(MSSA) and methicillin-resistant(MRSA). We investigated the pharmacodynamic activity of omadacycline against 10 MSSA/MRSA strains in a neutropenic murine thigh model. The median 24-h area under the concentration-time curve (AUC)/MIC values associated with net stasis and 1-log kill were 21.9 and 57.7, respectively.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31036691/