Peer-reviewed veterinary case report
How cats absorb two oral doses of THC and CBD herbal extract
By Lyons, Chloe et al.·Published in Frontiers in veterinary science·2024·Department of Veterinary Biomedical Sciences, Canada·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Pharmacokinetic of two oral doses of a 1:20 THC:CBDherbal extract in cats.
- Species:
- cat
Plain-English summary
Twelve healthy Domestic Shorthair cats were given a herbal extract containing THC and CBD to see how their bodies absorbed and processed it. The cats received either a low or high dose, and blood samples were taken for up to 48 hours afterward. The study found that both THC and CBD were absorbed quickly, but the levels varied significantly between cats. While some cats showed increased salivation after the high dose, there were no serious side effects like vomiting or changes in behavior. Overall, the cats tolerated the doses well, but the absorption might not be optimal when given on an empty stomach.
People also search for: cat CBD oil effects · THC CBD for cats · why is my cat drooling after medication
Abstract
OBJECTIVE: To determine the pharmacokinetics (PK) of two oral doses of aherbal extract (CHE) containing 1:20 THC:CBD in 12 healthy Domestic Shorthair cats. METHODS: Single-dose PK were assessed after oral administration of CHE at low or high dose (2 mg CBD + 0.1 mg THC, or 5 mg CBD + 0.25 mg THC per kg bw, respectively; = 6 per group) in fasting cats. Blood samples were drawn up to 48 h following CHE administration. Plasma samples were analyzed for CBD, THC, and metabolites 6-OH-CBD, 7-OH-CBD, 11-OH-THC, and THC-COOH using a previously validated LC-MS/MS method. RESULTS: CBD and THC were quickly absorbed (meanof 2.4-2.9 h). Maximum plasma concentrations () ranged from 36-511 ng/mL and 6.8-61 ng/mL for CBD and THC, respectively. Elimination was initially rapid for both CBD and THC, though a prolonged elimination phase was noted for CBD in some cats (Tup to 26 h). Dose-adjustedand AUCvalues were not statistically significantly different ( > 0.05) between dose groups indicating CBD and THC concentrations increased in a manner proportional (linear) to the dose. Dose-adjusted THCand AUCwere significantly higher than the corresponding dose-adjusted CBD parameters ( < 0.01). Low concentrations of the metabolite 6-OH-CBD were quantified but metabolites 7-OH-CBD, 11-OH-THC, and THC-COOH were not detected in any plasma samples. Inter-individual variance was notable. Salivation shortly after dosing was observed in two cats in the high dose group; these animals had substantially lower cannabinoid concentrations than other cats in this group. No adverse clinical signs (including vomiting, change in mentation or other neurological signs) were noted. CLINICAL SIGNIFICANCE: Although cats did not display adverse effects after administration of a single oral dose of 1:20 THC:CBD CHE formulation at 2 or 5 mg CBD/kg bw, observed plasma concentrations were highly variable but generally lower than in dogs receiving the same dose and formulation. Administration of CHE in the fasting state may not optimize CBD absorption, and oral dosing may be challenging when administering an oil-based CHE in some cats.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38585296/