Pharmacokinetics and Drug Residue in Eggs After Multiple-Day Oral Dosing of Amoxicillin-Clavulanic Acid in Domestic Chickens.

Abstract

This study examined the pharmacokinetics of orally administered amoxicillin and clavulanic acid tablets (Clavamox, 125 mg/kg PO q12h for 9 doses) in domestic hens and examined both amoxicillin and clavulanic acid concentrations in eggs. Therapeutic plasma concentrations (0.5 µg/mL) of amoxicillin were not reached at any time point, and no amoxicillin was detected in plasma after 2 hours. Pharmacokinetic parameters could not be calculated. The clavulanic acid half-life was 1.1 hours and it was detected up to 8 hours after dosing. No amoxicillin was detected in eggs 4 days postdosing, nor was clavulanic acid detected in any eggs during the same time period. On the basis of these results, orally dosing hens with amoxicillin and clavulanic acid tablets at 125 mg/kg PO q12h does not reach therapeutic plasma concentrations. Additional studies are needed to examine different doses and formulations of medication to determine better dosing and withdrawal recommendations for domestic chickens.