Peer-reviewed veterinary case report
How amoxicillin works in dogs and its dosing details
By Jeong, Ji-Soo et al.·Published in Pathogens (Basel, Switzerland)·2024·College of Veterinary Medicine (BK21 FOUR Program), South Korea·View original on PubMed →
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Original publication title: Pharmacokinetics and Pharmacodynamics Evaluation of Amoxicillin Againstin Dogs.
- Species:
- dog
Plain-English summary
A group of healthy dogs received a subcutaneous injection of amoxicillin, an antibiotic, to see how well it worked against bacterial infections. The study found that amoxicillin was effective against most strains of bacteria, maintaining levels in the dogs' systems that were high enough to fight the infection for over 80% of the time. However, one strain was more resistant and didn't respond as well. This research suggests that using amoxicillin at specific intervals can help treat infections in dogs more effectively.
People also search for: dog bacterial infection treatment · amoxicillin for dogs dosage · antibiotic resistance in dogs
Abstract
Antibiotic resistance in bacteria from companion animals poses significant public health risks. Prudent antibiotic use, particularly through pharmacokinetics/pharmacodynamics modeling, is crucial for minimizing resistance. We investigated the pharmacokinetics/pharmacodynamics of amoxicillin (AMX) against. A pharmacokinetic study was conducted on healthy dogs subcutaneously injected with a dose of 15 mg/kg AMX. The antibacterial efficacy of AMX was evaluated against a standard strain from animals (KCTC 3344) and clinical isolates from dogs (B-2, B-7, and B-8), with minimum inhibitory concentrations (MICs) of 0.25, 0.5, 64, and 16 μg/mL, respectively. The half-life of AMX was 7 h, allowing for extended drug efficacy. The time above MIC (%T > MIC) values indicated that the AMX concentrations were maintained above MICs of the two susceptible strains (KCTC 3344 and B-2) for more than 80% of the time when dosed at a one-day interval, suggesting an effective treatment. The area under the curve over 24 h/MIC ratios confirmed the bacteriostatic, bactericidal, and bacterial eradication effects of AMX againststrains, except for B-7 (the most resistant strain). These results support improved clinical dosing strategies for AMX againstinfections in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39770380/