Peer-reviewed veterinary case report
How cefquinome works against E. coli in Beagle dogs
By Zhou, Y F et al.·Published in Journal of veterinary pharmacology and therapeutics·2015·College of Veterinary Medicine, China·View original on PubMed →
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Original publication title: Pharmacokinetics, bioavailability and PK/PD relationship of cefquinome for Escherichia coli in Beagle dogs.
- Species:
- dog
Plain-English summary
A group of Beagle dogs were given a medication called cefquinome to treat infections caused by E. coli bacteria. The study looked at how well the drug worked when given through different methods: intravenously (IV), intramuscularly (IM), and subcutaneously (SC). It found that a dose of 2 mg/kg every 12 hours was effective in keeping drug levels high enough to fight the bacteria. This treatment showed promise in helping dogs recover from infections caused by E. coli.
People also search for: Beagle dog E. coli infection treatment · cefquinome for dogs · dog antibiotic dosage · how to treat bacterial infections in dogs
Abstract
The pharmacokinetics and bioavailability of cefquinome in Beagle dogs were determined by intravenous (IV), intramuscular (IM) or subcutaneous (SC) injection at a single dose of 2 mg/kg body weight (BW). The minimum inhibitory concentrations (MIC) of cefquinome against 217 Escherichia coli isolated from dogs were also investigated. After IV injection, the plasma concentration-time curve of cefquinome was analyzed using a two-compartmental model, and the mean values of t1/2α (h), t1/2β (h), Vss (L/kg), ClB (L/kg/h) and AUC (μg·h/mL) were 0.12, 0.98, 0.30, 0.24 and 8.51, respectively. After IM and SC administration, the PK data were best described by a one-compartmental model with first-order absorption. The mean values of t1/2Kel , t1/2Ka , tmax (h), Cmax (μg/mL) and AUC (μg·h/mL) were corresponding 0.85, 0.14, 0.43, 4.83 and 8.24 for IM administration, 0.99, 0.29, 0.72, 3.88 and 9.13 for SC injection. The duration of time that drug levels exceed the MIC (%T > MIC) were calculated using the determined MIC90 (0.125 μg/mL) and the PK data obtained in this study. The results indicated that the dosage regimen of cefquinome at 2 mg/kg BW with 12-h intervals could achieve %T > MIC above 50% that generally produced a satisfactory bactericidal effect against E. coli isolated from dogs in this study.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25776615/