Peer-reviewed veterinary case report
Pharmacokinetics of buprenorphine following intravenous and oral transmucosal administration in dogs.
- Journal:
- Veterinary therapeutics : research in applied veterinary medicine
- Year:
- 2008
- Authors:
- Abbo, Lisa A et al.
- Affiliation:
- Department of Veterinary Clinical Sciences · United States
- Species:
- dog
Abstract
Pharmacokinetic analysis of buprenorphine administered to six healthy dogs via the oral transmucosal (OTM) route at doses of 20 and 120 microg/kg was conducted using liquid chromatography-electrospray ionization-tandem mass spectroscopy (LC-ESI-MS/MS). Bioavailability was 38% plus or minus 12% for the 20 microg/kg dose and 47%+/-16% for the 120 microg/kg dose. Maximum plasma concentrations were similar for buprenorphine doses of 20 microg/kg IV and 120 microg/kg OTM. Sedation and salivation were common side effects, but no bradycardia, apnea, or cardiorespiratory depressive effects were seen. When the two OTM dosing rates were normalized to dose, LC-ESI-MS/MS analysis of buprenorphine and its metabolites detected no significant difference (P>.05), indicating dose proportionality. The results of this study suggest that OTM buprenorphine may be an alternative for pain management in dogs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18597246/