Peer-reviewed veterinary case report
How buprenorphine is absorbed and processed in dogs after IV
By Abbo, Lisa A et al.·Published in Veterinary therapeutics : research in applied veterinary medicine·2008·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Pharmacokinetics of buprenorphine following intravenous and oral transmucosal administration in dogs.
- Species:
- dog
Plain-English summary
A group of six healthy dogs received buprenorphine, a pain medication, either through an injection or by placing it in their mouths for absorption. The oral method showed that the medication was effective, with about 38% to 47% of the dose reaching the bloodstream. While some dogs experienced sedation and drooling, there were no serious side effects like slow heart rate or breathing problems. This suggests that giving buprenorphine orally could be a good option for managing pain in dogs.
People also search for: dog pain medication buprenorphine · oral pain relief for dogs · side effects of buprenorphine in dogs
Abstract
Pharmacokinetic analysis of buprenorphine administered to six healthy dogs via the oral transmucosal (OTM) route at doses of 20 and 120 microg/kg was conducted using liquid chromatography-electrospray ionization-tandem mass spectroscopy (LC-ESI-MS/MS). Bioavailability was 38% plus or minus 12% for the 20 microg/kg dose and 47%+/-16% for the 120 microg/kg dose. Maximum plasma concentrations were similar for buprenorphine doses of 20 microg/kg IV and 120 microg/kg OTM. Sedation and salivation were common side effects, but no bradycardia, apnea, or cardiorespiratory depressive effects were seen. When the two OTM dosing rates were normalized to dose, LC-ESI-MS/MS analysis of buprenorphine and its metabolites detected no significant difference (P>.05), indicating dose proportionality. The results of this study suggest that OTM buprenorphine may be an alternative for pain management in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18597246/