Peer-reviewed veterinary case report
Pharmacokinetics of ciprofloxacin in normal rabbits and changes observed in induced dehydrated state.
- Journal:
- Pakistan journal of pharmaceutical sciences
- Year:
- 2008
- Authors:
- Bashir, Sajid et al.
- Affiliation:
- Department of Pharmacy
- Species:
- rabbit
Abstract
The pharmacokinetics of ciprofloxacin following oral administration of a single dose of 20 mg/kg body weight was investigated in normal rabbits and changes were observed in water-deprived rabbits. High performance liquid chromatographic method was employed for the determination of plasma concentration of ciprofloxacin. The mean plasma concentration and AUC (0-t) and AUC (0-inf) were significantly different between normal and dehydrated rabbits (P<0.05), but the absorption rate, distribution rate, and elimination rate did not show any statistically significant difference. The results reflect a need for monitoring toxicity of ciprofloxacin in the water-deprived condition.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18614416/