Peer-reviewed veterinary case report
How imipenem antibiotic works in cats after different injections
By Albarellos, Gabriela A et al.·Published in Journal of feline medicine and surgery·2013·Department of Pharmacology·View original on PubMed →
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Original publication title: Pharmacokinetics of imipenem after intravenous, intramuscular and subcutaneous administration to cats.
- Species:
- cat
Plain-English summary
Five adult cats were given imipenem, an antibiotic, through different methods: intravenously (IV), intramuscularly (IM), and subcutaneously (SC), to see how well it worked against tough bacterial infections. The study found that all tested bacteria from cat infections were sensitive to imipenem, meaning it could effectively treat these infections. The highest levels of the drug were found in the bloodstream after IV administration, but it remained effective for several hours regardless of the method used. While the results are promising, more clinical trials are needed to confirm the best way to use imipenem for treating infections in cats.
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Abstract
The study describes the pharmacokinetics and predicted efficacy of imipenem after intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration to five adult cats at a dose of 5 mg/kg. Susceptibility to imipenem [minimum inhibitory concentration (MIC)] was determined for antimicrobial resistant Escherichia coli (n = 13) and staphylococci (n = 3) isolated from domestic cat infections (urinary system, skin and conjunctiva). Maximum plasma concentrations of imipenem were 13.45 µg/ml (IV), 6.47 µg/ml (IM) and 3.83 µg/ml (SC). Bioavailability was 93.18% (IM) and 107.90% (SC). Elimination half-lives for IV, IM and SC administration were 1.17, 1.44 and 1.55 h, respectively. All tested bacteria were susceptible to imipenem; MIC values were 0.03 µg/ml for Staphylococcus species and <0.25-0.5 µg/ml for E coli. Mean imipenem concentrations remained above a MIC of 0.5 µg/ml for approximately 4 h (IV and IM) and 9 h (SC). Imipenem would be predicted to be effective for the treatment of antimicrobial resistant bacterial infections in cats at a dosage of 5 mg/kg every 6-8 h (IV, IM), or longer for the SC route. However, clinical trials are mandatory to establish its efficacy and proper dosing.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23253883/