Peer-reviewed veterinary case report
How ponazuril medicine is absorbed in cats after one oral dose
By Burlison, Catherine et al.·Published in Journal of veterinary pharmacology and therapeutics·2022·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Pharmacokinetics of orally administered single-dose ponazuril in cats.
- Species:
- cat
Plain-English summary
A group of six healthy adult cats received a single dose of ponazuril, a medication used to treat coccidiosis, a serious intestinal infection that can be fatal. After taking the medication, the cats showed effective levels of the drug in their blood, which can help stop the growth of the parasites causing the infection. While this study indicates that ponazuril can be effective, more research is needed to determine the best dosing for treating cats with coccidiosis.
People also search for: cat coccidiosis treatment · ponazuril for cats · symptoms of coccidiosis in cats
Abstract
Cats and kittens in animal shelters and catteries regularly suffer from severe gastrointestinal coccidiosis, which can be fatal, and there are no drugs labeled for feline coccidiosis in the United States. Ponazuril, a triazine-class drug, is increasingly used at a dose of 50 mg/kg/d, orally, for three to five days in shelter environments for coccidiosis. A single oral dose of ponazuril paste 15% (Marquis; Merial) at 50 mg/kg was administered to six healthy adult cats. Sample analysis was completed via high-performance liquid chromatography. Plasma concentrations peaked at 7.49 ± 2.06 µg/ml at 14.67 ± 7.45 hr post-administration. This study shows that ponazuril achieved a plasma concentration that inhibits growth of similar organisms after a single oral dose in cats. Further studies are necessary to optimize dosing for the treatment of clinical coccidiosis in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35307837/