Peer-reviewed veterinary case report
How enoxaparin injections work in dogs for blood thinning
By Lunsford, Kari V et al.Ā·Published in Journal of the American Animal Hospital AssociationĀ·2009Ā·Department of Clinical Sciences, United StatesĀ·View original on PubMed ā
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Original publication title: Pharmacokinetics of subcutaneous low molecular weight heparin (enoxaparin) in dogs.
- Species:
- dog
Plain-English summary
A study looked at how well a low molecular weight heparin called enoxaparin works in dogs when given under the skin. The researchers found that giving enoxaparin at a dose of 0.8 mg/kg every six hours kept the drug levels stable in the dogs' blood without causing any bleeding problems. This means that enoxaparin could be a safer and easier option for preventing blood clots in dogs compared to traditional heparin, which requires more monitoring.
People also search for: dog blood thinner enoxaparin Ā· dog anticoagulant medication Ā· how often to give enoxaparin to dogs
Abstract
Unfractionated heparin has been the standard heparin used in human and veterinary medicine for its anticoagulation effect; however, it has a complex pharmacodynamic profile that requires close monitoring. Low molecular weight heparins have a more predictable bioavailability, allowing standardized dosing without individual patient monitoring. This project was designed to a) evaluate the pharmacokinetics of the subcutaneous (SC) administration of the low molecular weight heparin, enoxaparin, in dogs using anti-Xa activity as a marker of plasma enoxaparin concentrations and b) to establish the dose necessary to maintain activity within an established target range. Enoxaparin at 0.8 mg/kg SC q 6 hours consistently maintained target levels of anti-Xa activity in normal dogs without evidence of hemorrhagic complications.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19887383/