Peer-reviewed veterinary case report
Ciprofloxacin eye drops in tears of mesocephalic and brachycephalic
By Hendrix, Diane V H & Cox, Sherry K·Published in Veterinary ophthalmology·2008·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Pharmacokinetics of topically applied ciprofloxacin in tears of mesocephalic and brachycephalic dogs.
- Species:
- dog
Plain-English summary
A study looked at how well ciprofloxacin, an antibiotic eye drop, works in the tears of normal dogs with different head shapes. The researchers applied the drops to both eyes of 35 dogs and measured the concentration of the medication in their tears over six hours. They found that the levels of ciprofloxacin stayed high enough to fight most bacteria for the entire duration in both mesocephalic (normal-shaped) and brachycephalic (flat-faced) dogs. This means that ciprofloxacin can be effective for treating eye infections in these types of dogs.
People also search for: dog eye infection treatment · ciprofloxacin for dogs · brachycephalic dog eye drops
Abstract
OBJECTIVE: To evaluate the pharmacokinetics of ophthalmic ciprofloxacin in the tear film of normal mesocephalic and brachycephalic dogs. ANIMALS STUDIED: Twenty mesocephalic dogs and 15 brachycephalic dogs. PROCEDURES: Thirty-five microliters of ciprofloxacin were placed on the cornea of both eyes of each dog. Five brachycephalic dogs were used twice. A tear-test strip placed in the ventral cul de sac for 30 s was used to obtain samples. The tear film of each eye was sampled once at eight time-points post administration, resulting in five samples at each time-point. Samples were evaluated using high performance liquid chromatography. Data from the two skull types were compared using the unpaired two-tailed t-test. RESULTS: The mean concentration of ciprofloxacin in the tears of mesocephalic dogs was 192.8 +/- 269.97, 140.6 +/- 91.06, 56.60 +/- 28.47, 13.6 +/- 6.3, 43.25 +/- 59.71, 16.6 +/- 10.62, 15.6 +/- 13.16 and 6.25 +/- 9.84 microg/g at 5, 10, 15, 30 min and 1, 2, 4 and 6 h, respectively. The mean concentration of ciprofloxacin in the tears of brachycephalic dogs was 272.6 +/- 106.21, 144.4 +/- 142.32, 131.2 +/- 147.07, 75 +/- 80.07, 40.8 +/- 30.35, 35 +/- 21.98, 52.75 +/- 51.87 and 8.6 +/- 12.10 microg/g at 5, 10, 15, 30 min and 1, 2, 4 and 6 h, respectively. There was no statistical difference in tear concentration at any time-point between skull types. CONCLUSIONS: Topical application of ciprofloxacin resulted in a mean tear concentration of ciprofloxacin that remained above the MIC(90) levels for most pathogenic bacteria for 6 h in normal mesocephalic and brachycephalic dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18190345/