Peer-reviewed veterinary case report
Long-term results of drug treatment for chronic glaucoma in dogs
By Julien, Martha E et al.·Published in Veterinary ophthalmology·2021·BluePearl Veterinary Partners, United States·View original on PubMed →
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Original publication title: Pharmacologic ciliary body ablation for chronic glaucoma in dogs: A retrospective review of 108 eyes from 2013 to 2018.
- Species:
- dog
Plain-English summary
A group of dogs with chronic glaucoma underwent a treatment involving injections of gentamicin and dexamethasone to help lower their eye pressure. Out of 108 eyes treated, 95% showed improvement, with many dogs able to stop using their eye pressure medications after the procedure. Most of the dogs had primary glaucoma, and while some experienced complications like corneal swelling or eye pain, the treatment was generally effective. This approach can be a good option for dogs suffering from severe glaucoma to help manage their condition.
People also search for: dog glaucoma treatment · eye pressure medication for dogs · Cocker Spaniel glaucoma injections
Abstract
OBJECTIVE: To evaluate the long-term outcome and efficacy of intravitreal injection of gentamicin and dexamethasone sodium phosphate (IVGD) or triamcinolone in end-stage glaucoma patients and determine pre-procedure prognostic indicators of success and post-operative complications. PROCEDURE: Medical records were reviewed for 108 dogs (108 eyes) treated with intravitreal gentamicin with or without dexamethasone sodium phosphate or triamcinolone for glaucoma between 2013 and 2018 with 3 months of minimum follow-up. Signalment and clinical findings, including type of glaucoma, pre-procedure intraocular pressure (IOP), chronicity, procedure protocol, and outcome were recorded. Success was defined as an intraocular pressure of ≤25 mm Hg at the time of last re-examination or no ocular hypotensive medications at 3 months or longer post-injection. RESULTS: The overall success rate for pharmacologic ablation was 95%. The success rate for dogs receiving no ocular hypotensive medications was 86%. Seventy-six eyes (70.4%) had primary glaucoma, and 32 eyes (29.6%) had secondary glaucoma. Age at the time of injection had no effect on initial success but did in final success (P =-.03) for dogs requiring repeat injections. Cocker Spaniels required the most repeat 2nd and 3rd injections (3/12 dogs) and (2/4 dogs), respectively. No preoperative variable significantly affected the success rate. The most common complications were phthisis bulbi (59.2%), corneal edema (25.9%), and ulcerative keratitis (22.3%). Uncontrolled IOP resulted in enucleation in two dogs (1.8%). CONCLUSIONS: Pharmacologic ablation has a high overall success rate in lowering IOP to ≤25 mm Hg short-term in blind, glaucomatous canine eyes. Type of glaucoma, pre-procedure IOP, chronicity, and protocol did not affect success.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32857917/