Peer-reviewed veterinary case report
Bradykinin blocker drug did not ease arthritis pain in dogs
By Duclos, B A et al.·Published in Journal of veterinary pharmacology and therapeutics·2017·Global Therapeutics Research, United States·View original on PubMed →
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Original publication title: Pharmacological evaluation of a selective bradykinin Bantagonist in a canine model of arthritis.
- Species:
- dog
Plain-English summary
A group of dogs with arthritis were given a new medication to see if it could help reduce their pain and improve their ability to bear weight on their legs. Unfortunately, the treatment did not show any improvement in their condition, even though the medication was present in their system. This suggests that the specific receptor targeted by the medication may not be effective in managing pain from arthritis in dogs.
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Abstract
The effects of a selective bradykinin 1 receptor antagonist, compound A, were evaluated in a canine model of acute inflammatory model of arthritis. Despite detection of the Breceptor in canine type B synoviocytes using a fluorescent ligand, oral administration of compound A (9 and 27 mg/kg) did not improve weight bearing of dogs injected intra-articularly with IL-1β in a force plate analysis. Analysis of the synovial fluid of IL-1β-treated dogs indicated high levels of bradykinin postchallenge. Excellent exposure, coupled with evidence of the presence of the Breceptor during an acute inflammatory model of pain, indicates an inability of the receptor to mediate inflammatory pain in canines.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27345291/