Peer-reviewed veterinary case report
Phenotypic analysis of hepatic T lymphocytes in a dog with chronic hepatitis.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2006
- Authors:
- Sakai, Manabu et al.
- Affiliation:
- Department of Veterinary Medicine · Japan
- Species:
- dog
Abstract
We evaluated hepatic T lymphocyte phenotypes in a dog with chronic hepatitis. Before treatment, numerous CD3+ lymphocytes were demonstrated in the liver, and the ratio of CD4+/CD8+ was remarkably high (2.96; reference range, 0.33+/-0.12). After treatment, CD3+ lymphocyte infiltration in the liver was reduced, and the ratio of CD4+/CD8+ decreased to 0.31. Therefore, hepatic T lymphocytes, especially CD4+ lymphocytes, might play a central role in the pathogenesis of this dog with chronic hepatitis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17146184/