Peer-reviewed veterinary case report
Changes in liver T cells in a dog with chronic hepatitis
By Sakai, Manabu et al.·Published in The Journal of veterinary medical science·2006·Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Phenotypic analysis of hepatic T lymphocytes in a dog with chronic hepatitis.
- Species:
- dog
Plain-English summary
A 5-year-old dog with chronic hepatitis was found to have an unusually high number of certain immune cells in its liver before treatment. After receiving treatment, the number of these immune cells decreased significantly, suggesting that they were contributing to the liver problem. This indicates that specific immune cells may play a key role in the liver disease of this dog. The treatment helped improve the dog's condition by reducing the harmful immune response in the liver.
People also search for: dog chronic hepatitis treatment · liver disease in dogs · immune system and dog liver problems
Abstract
We evaluated hepatic T lymphocyte phenotypes in a dog with chronic hepatitis. Before treatment, numerous CD3+ lymphocytes were demonstrated in the liver, and the ratio of CD4+/CD8+ was remarkably high (2.96; reference range, 0.33+/-0.12). After treatment, CD3+ lymphocyte infiltration in the liver was reduced, and the ratio of CD4+/CD8+ decreased to 0.31. Therefore, hepatic T lymphocytes, especially CD4+ lymphocytes, might play a central role in the pathogenesis of this dog with chronic hepatitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17146184/