Peer-reviewed veterinary case report
Blood markers linked to canine atopic dermatitis skin allergy
By Koury, Jeffrey et al.·Published in PloS one·2019·Graduate College of Biomedical Sciences, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Phosphodiesterase 4D, miR-203 and selected cytokines in the peripheral blood are associated with canine atopic dermatitis.
- Species:
- dog
Plain-English summary
A study found that dogs with atopic dermatitis (AD), a common skin allergy, showed higher levels of certain genes and molecules in their blood compared to healthy dogs. This suggests that these markers might help in understanding and diagnosing AD, which can be tricky since it shares symptoms with other skin issues. Currently, diagnosing AD relies on a mix of history, exams, and allergy tests, but no reliable blood tests exist yet. More research is needed to confirm these findings and see if they can be used in practice.
People also search for: dog skin allergy symptoms · atopic dermatitis treatment for dogs · how to diagnose dog allergies
Abstract
Canine Atopic Dermatitis (AD) is a common complex and multifactorial disease involving immune dysregulation, genetic predisposition, skin barrier defects, environmental factors and allergic sensitization. To date, diagnosis of canine AD relies on a combination of patient history, clinical examination, allergy testing and response to diet trials/therapies with no reliable biomarkers available to distinguish AD from other diseases with similar clinical presentations. A handful of studies to identify potential biomarkers in the peripheral blood of AD dogs and healthy controls have been performed with some showing inconsistent and contradictory results. In this study, we, for the first time, report statistically significant increases in expression of phosphodiesterase 4D (PDE4D) gene in peripheral blood mononuclear cells (PBMCs) and miR-203 in plasma from AD dogs compared to healthy controls. In addition, we report a statistically non-significant change of the CD4+/CD8+ ratio, a dramatic decrease of three gene markers (PIAS1, RORA and SH2B1) as well as a panel of differential expression of cytokines in AD dogs in comparison to the healthy controls. Our study provides important insight into the complexities of canine AD, and further studies to verify the specificity of these findings for canine AD at a larger-scale are warranted.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31226136/