Peer-reviewed veterinary case report
Targeting focal adhesion kinase in canine hemangiosarcoma cells
By Marley, K et al.·Published in Veterinary and comparative oncology·2012·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Phosphotyrosine enrichment identifies focal adhesion kinase and other tyrosine kinases for targeting in canine hemangiosarcoma.
- Species:
- dog
Plain-English summary
A study found that a specific type of cancer in dogs called hemangiosarcoma (HSA) is influenced by certain proteins that help the cancer cells grow and survive. Researchers discovered that a protein called focal adhesion kinase (FAK) is often activated in these cancer cells, which helps them move and thrive. When they used a special medication that blocks FAK, it not only stopped the cancer cells from moving but also killed them. This suggests that targeting FAK could be an effective treatment for dogs suffering from hemangiosarcoma.
People also search for: dog hemangiosarcoma treatment · canine cancer medication · focal adhesion kinase inhibitor for dogs
Abstract
Canine hemangiosarcoma (HSA) is an endothelial cell malignancy driven, in part, by activating mutations in receptor and non-receptor tyrosine kinases. Proteomics, Western blots and a tyrosine kinase inhibitor were used to elucidate activating mechanisms in HSA cell lines. Phosphotyrosine peptides from focal adhesion kinase (FAK) STAT3, Lyn, Fyn and other signal transduction kinases were identified by mass spectrometry. FAK was constitutively activated at tyrosine 397, the autophosphorylation site, and this was reversible with high concentrations of a FAK inhibitor. FAK inhibitor-14 suppressed migration and phosphorylation of FAK tyrosine 397 and tyrosines 576/577 and was cytotoxic to HSA cells suggesting FAK signalling may be an important contributor to canine HSA survival.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22487216/