Peer-reviewed veterinary case report
Photodynamic therapy with bronchoscopy for dog lung cancer
By Musani, Ali I et al.·Published in Lasers in surgery and medicine·2018·University of Colorado Medical School·View original on PubMed →
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Original publication title: Photodynamic therapy via navigational bronchoscopy for peripheral lung cancer in dogs.
- Species:
- dog
Plain-English summary
A 10-year-old Beagle, a 7-year-old Labrador, and a 9-year-old Golden Retriever were diagnosed with peripheral lung cancer and treated with a special light therapy called photodynamic therapy (PDT) using navigational bronchoscopy. This involved giving the dogs a photosensitizing drug followed by a laser treatment to target the tumors. After a week, the tumors were surgically removed and showed that the treatment was effective, with manageable side effects. The dogs tolerated the procedure well, and the therapy minimized damage to healthy lung tissue.
People also search for: dog lung cancer treatment · photodynamic therapy for dogs · Beagle lung tumor symptoms
Abstract
OBJECTIVE: In the setting of lung cancer, photodynamic therapy (PDT) is typically used to treat centrally located endobronchial tumors. The development of navigational bronchoscopy has opened the potential for using PDT to treat peripheral lung tumors. However, there is limited information about the feasibility of this approach for treating peripheral lung cancers, and about its effects on surrounding healthy lung tissue. We studied the use of PDT delivered by electromagnetic navigational bronchoscopy to treat peripheral lung cancer in dogs. MATERIALS AND METHODS: Three dogs with peripheral lung adenocarcinomas were given intravenous porfimer sodium (Photofrin® [Pinnacle Biologics, Inc., Chicago, IL]) to photosensitize the tumors, then navigational bronchoscopy was used to deliver photoradiation. One week after PDT, the tumors and involved lung lobe were surgically excised and evaluated histologically. RESULTS: PDT was successful in all three dogs and was associated with tolerable and manageable adverse effects. Tissue sections from within PDT-treated tumors showed regions of coagulative central necrosis admixed with small numbers of inflammatory cells, and arterial thrombosis. Viable adenocarcinoma was seen in the surrounding areas. CONCLUSION: These results suggest that PDT can be successfully deployed to treat peripheral lung cancers using navigational bronchoscopy. Furthermore, damage to surrounding noncancerous tissues can be minimized with accurate placement of the optical fiber. Studies of this modality to treat peripheral lung cancers in humans may be warranted. Lasers Surg. Med. 50:483-490, 2018. © 2018 Wiley Periodicals, Inc.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29399826/