Peer-reviewed veterinary case report
Feline immunodeficiency virus subtype B diversity found in cats
By Perharić, Matko et al.·Published in Archives of virology·2016·Department of Microbiology and Infectious Diseases with Clinic·View original on PubMed →
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Original publication title: Phylogenetic characterisation of feline immunodeficiency virus in naturally infected cats in Croatia indicates additional heterogeneity of subtype B in Europe.
- Species:
- cat
Plain-English summary
A group of 29 domestic cats in Croatia showed various health issues that might be linked to feline immunodeficiency virus (FIV). Blood tests were done to check for FIV antibodies, and 11 cats tested positive for the virus. Further genetic analysis revealed that these positive cases belonged to subtype B of FIV, with some differences among the strains. Understanding these variations can help improve testing and vaccine options for affected cats.
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Abstract
This study was performed on 29 domestic cats with a variety of clinical signs, possibly related to FIV infection. Blood samples were tested by a rapid immunochromatographic (ICA) procedure for detection of FIV antibodies. Subsequently, polymerase chain reaction (PCR) was performed to amplify a portion of the proviral gag gene. All 11 positive PCR products were sequenced and compared with previously reported FIV sequences. Croatian proviral isolates that could be amplified were clustered within subtype B, and additional heterogeneity was confirmed by the formation of three separate clusters. Phylogenetic analysis of circulating strains in Croatia and in southeast Europe is necessary to improve diagnostic methods and selection of the appropriate vaccinal strains.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27318929/