Peer-reviewed veterinary case report
Comparison of ear infection treatments for dogs with otitis externa
By Song, Yunmei et al.·Published in BMC veterinary research·2023·University of South Australia, Australia·View original on PubMed →
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Original publication title: Physicochemical properties of otic products for Canine Otitis Externa: comparative analysis of marketed products.
- Species:
- dog
Plain-English summary
A dog with ear infections, known as otitis externa, often shows signs like scratching at the ears, shaking the head, or a bad smell coming from the ears. In a study comparing different ear drop products for dogs, it was found that some products worked better than others based on their thickness and how easily they spread. Aqueous-based drops were easier to use, while oil-based drops required more effort to apply. The study highlighted that products like Derm Otic and Baytril Otic provided more consistent dosing, which can help in effectively treating ear infections in dogs.
People also search for: dog ear infection treatment · best ear drops for dogs · why is my dog shaking his head
Abstract
BACKGROUND: Otitis externa is a commonly diagnosed dermatological disorder in canines. The pathogens primarily involved in canine otitis externa (COE) include Staphylococcus pseudintermedius, Pseudomonas aeruginosa, Proteus mirabilis, and Malassezia pachydermatis. As COE tends to be superficial, medications delivered topically are often effective and practical in managing the condition. As such, there is a wide variety of approved topical products currently available in the market. The efficacy of topical dosage forms can be dependent on various factors such as the pharmacology of active constituents and the physicochemical properties of the formulation, including pH, viscosity, spreadability, and bio-adhesion. Currently, there is a lack of published literature available on the optimal properties of topical COE products. In this study, we compared the physicochemical properties of nine commercially available otic veterinarian products in Australia used clinically to manage COE. RESULTS: Based on our comparative analysis, the pH (6.26 ± 0.04) of an aqueous-based product was similar to a healthy dog's external auditory canal. Products containing polymers exhibited higher viscosity and bio-adhesion. Spreadability was inversely related to viscosity and Osurnia ® a product with high viscosity demonstrated the lowest spreadability. Aqueous-based otic products showed better syringebility whereas oil-based systems required higher force to expel the products. Variability in droplet size was noted. Derm Otic, Baytril Otic, and Aurizon Ear Drops had the lower standard deviation which indicates they would give a more consistent dose. CONCLUSIONS: Findings from this work provide considerations for industry researchers or formulation scientists working in the area of otic dosage formulations.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36759841/