Peer-reviewed veterinary case report
Picrotoxin-induced convulsions alters rat brain microsomal membrane structural properties.
- Journal:
- Neuroscience letters
- Year:
- 2006
- Authors:
- Acharya, Munjal M & Katyare, Surendra S
- Affiliation:
- Department of Biochemistry and Biotechnology · India
- Species:
- rodent
Abstract
Cerebral microsomal membrane properties were assessed in the chronic condition of generalized seizure induced by picrotoxin (PTX) in rats. PTX-induced seizures resulted in increased lysophosphatidyl glycerol, phosphatidylcholine and phosphatidic acid components, while phosphatidylethanolamine, phosphatidylserine and phosphatidylinositol were significantly reduced by 19-73%. The cholesterol (CHL) content increased considerably by 25% without alteration in total phospholipids content. Microsomal membrane was more fluidized in the epileptic condition. Possible consequences of microsomal membrane alterations are discussed in terms of deregulation of Ca2+ homeostasis. In conclusion, alterations in the microsomal membrane properties may have a significant influence on the cerebral function in the chronic epileptic condition.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16368191/