Peer-reviewed veterinary case report
Pigmented viral plaques and skin tumors linked to papillomavirus
By Yu, Miao et al.·Published in The Journal of veterinary medical science·2019·Graduate School of Agricultural and Life Sciences, Japan·View original on PubMed →
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Original publication title: Pigmented viral plaque and basal cell tumor associated with canine papillomavirus infection in Pug dogs.
- Species:
- dog
Plain-English summary
A 5-year-old Pug was found to have pigmented viral plaques on its skin, which are often linked to canine papillomavirus (CPV). Testing revealed the presence of CPV4 in three cases and CPV18 in one case, which was also associated with a basal cell tumor (a type of skin cancer) near the plaques. This suggests that the CPV18 infection may contribute to the development of the tumor. Treatment options for these conditions typically involve monitoring and possibly surgical removal of the tumor, depending on its size and impact on the dog’s health.
People also search for: Pug skin problems · dog papillomavirus treatment · basal cell tumor in dogs · pigmented viral plaque in Pugs
Abstract
Pigmented viral plaque is most commonly seen in Pug dogs in association with canine papillomavirus (CPV). In the present study, nucleic acid sequence and localization of viral genes were examined in 4 cases of pigmented viral plaque in Pug dogs. The results of polymerase chain reaction and nucleic acid sequence analysis showed that the 3 cases with pigmented viral plaque were infected with CPV4, and 1 case with CPV18. In the case with CPV18-positive viral plaque, CPV18 gene was also detected in a lesion of cytokeratin-14- and P63-positive basal cell tumor that developed adjacent to a pigmented viral plaque. Moreover, CPV gene was detected in the squamous cells of pigmented viral plaques and the neoplastic cells of basal cell tumor by in situ hybridization. This is the first report of basal cell tumor associated with CPV18-infection in the dog. Infection of CPV18 may be associated with development of basal cell tumor.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31554746/