Peer-reviewed veterinary case report
PIK3CA-related overgrowth spectrum: animal model and drug discovery.
- Journal:
- Comptes rendus biologies
- Year:
- 2021
- Authors:
- Venot, Quitterie & Canaud, Guillaume
- Affiliation:
- Inserm U1151 · France
Abstract
This review recapitulates the recent knowledge accumulation on overgrowth syndrome related to gain of function of the phosphoinositide3 kinase (PI3K)-alpha. These disorders, known as PIK3CA related overgrowth syndromes (PROS) are caused by somatic PIK3CA mutation occurring during embryogenesis. We summarize here the currently available animal models and new treatments undergoing development.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34213856/