Peer-reviewed veterinary case report
Topical treatment to reduce paw itching in dogs with atopic dermatitis
By Tamamoto-Mochizuki, Chie et al.·Published in Veterinary dermatology·2018·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Pilot evaluation of the antipruritic efficacy of a topical transient receptor potential melastatin subfamily 8 (TRPM8) agonist in dogs with atopic dermatitis and pedal pruritus.
- Species:
- dog
Plain-English summary
A group of nine dogs with atopic dermatitis (a skin condition causing itching) were treated with a new cooling cream called Cryosim-1 to see if it would help reduce their paw itching. The dogs received the cream twice a day for a week, but the results showed that it didn't work better than a placebo cream. After the treatment, only a few dogs showed improvement in their itching scores, and there was no significant difference between the two creams. Unfortunately, the new treatment did not prove to be effective in relieving the itching compared to the regular cream.
People also search for: dog itching treatment · atopic dermatitis in dogs · Cryosim-1 for dog itching · paw itching in dogs · how to help my dog with itchy paws
Abstract
BACKGROUND: Atopic dermatitis (AD) requires a multimodal therapy and there is a need for effective adjunctive interventions. TRPM8 agonists are known to alleviate pruritus by inducing cooling. OBJECTIVES: To evaluate the efficacy of a novel TRPM8 agonist, 1-diisopropylphosphorylheptane (Cryosim-1), in atopic dogs. ANIMALS: Nine client owned dogs with moderate to severe pedal pruritus associated with nonseasonal AD. METHODS: This was a prospective, randomized, double-blinded, intraindividual, placebo-controlled study. A 2% Cryosim-1 or placebo-vehicle cream was applied to each forepaw twice daily for seven days. The owner rated the pruritus manifestations once daily using a pedal Pruritus Visual Analog Scale (PVAS) and provided a Owner's Global Assessment of Treatment Efficacy (OGATE) at study end. RESULTS: After seven days, the numbers of dogs with a pedal PVAS <2.0 for Cryosim-1 and placebo were three and five of nine, respectively; likewise, OGATE scores of good-to-excellent were two and five of eight, respectively - these proportions were not significant between treatment groups (P = 0.32 and 0.16, respectively). Furthermore, there was no significant difference between Cryosim-1 and placebo in the median percentage change from baseline PVAS (47% versus 75%; P = 0.15) and in the number of dogs with a ≥50% or a ≥90% reduction from baseline pedal PVAS (four of nine versus five of nine, P = 0.50; two of nine versus two of nine, P = 0.72). CONCLUSIONS: In this pilot trial with a TRPM8 agonist in atopic dogs with pedal pruritus, the twice daily application of a 2% Cryosim-1 cream did not have an antipruritic effect superior to that of its vehicle.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28952176/