Peer-reviewed veterinary case report
Using PET-CT scans to study glucose uptake in dog mast cell tumors
By Griffin, Lynn R et al.·Published in Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·2018·Department of Environmental and Radiological Health Sciences (ERHS), United States·View original on PubMed →
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Original publication title: Pilot study utilizing Fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography for glycolytic phenotyping of canine mast cell tumors.
- Species:
- dog
Plain-English summary
A group of dogs with mast cell tumors, a type of skin cancer, underwent advanced imaging with a special scan (F18 FDG PET-CT) to see if it could help determine how aggressive their tumors were. The study included nine dogs, and while the results suggested a possible link between how much glucose the tumors absorbed and their grade, the findings weren't strong enough to conclude that this scan was better than traditional methods like ultrasounds and X-rays. More research is needed to fully understand the relationship between glucose use and the behavior of these tumors.
People also search for: dog mast cell tumor treatment · canine cancer glucose uptake · mast cell tumor staging in dogs
Abstract
The goal of this prospective pilot study was to use naturally occurring canine mast cell tumors of various grades and stages as a model for attempting to determine how glucose uptake and markers of biologic behavior are correlated. It was hypothesized that enhanced glucose uptake, as measured by 2-[fluorine-18]fluoro-d-glucose-positron emission tomography/computed tomography (F18 FDG PET-CT), would correlate with histologic grade. Dogs were recruited for this study from a population referred for treatment of cytologically or histologically confirmed mast cell tumors. Patients were staged utilizing standard of care methods (abdominal ultrasound and three view thoracic radiographs), followed by a whole body F18 FDG PET-CT. Results of the F18 FDG PET-CT were analyzed for possible metastasis and standard uptake value maximum (SUV) of identified lesions. Incisional or excisional biopsies of the accessible mast cell tumors were obtained and histology performed. Results were then analyzed to look for a possible correlation between the grade of mast cell tumors and SUV. A total of nine animals were included in the sample. Findings indicated that there was a correlation between grade of mast cell tumors and SUVas determined by F18 FDG PET-CT (p-value = 0.073, significance ≤ 0.1). Based on the limited power of this study, it is felt that further research to examine the relationship between glucose utilization and biologic aggressiveness in canine mast cell tumors is warranted. This study was unable to show that F18 FDG PET-CT was a better staging tool than standard of care methods.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29570234/