Peer-reviewed veterinary case report
Pin1 Knockout Mice: A Model for the Study of Tau Pathology in Alzheimer's Disease.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2017
- Authors:
- Kondo, Asami et al.
- Affiliation:
- Department of Medicine and the Cancer Center · United States
- Species:
- rodent
Abstract
Pin1 knockout in mice causes age-dependent neuropathy characterized by motor and behavioral deficits, tau hyper phosphorylation, tau filament formation, and neuronal degradation. Here, we describe the methods with mouse behavior test, immunostaining, and immunoblotting to detect many aspects of neurodegeneration in Pin1 knockout mice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27975268/