Peer-reviewed veterinary case report
Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus.
- Journal:
- Journal of medical microbiology
- Year:
- 2011
- Authors:
- Mirza, Zahid Mehmood et al.
- Affiliation:
- Department of Biochemistry · India
- Species:
- rodent
Abstract
Piperine, a trans-trans-isomer of 1-piperoyl-piperidine, was tested in combination with mupirocin for antimicrobial activity against Staphylococcus aureus strains including meticillin-resistant S. aureus. The combination markedly reduced the MIC of mupirocin and also lowered the mutation frequency. Enhanced accumulation and efflux of ethidium bromide from wild-type and mutant (Mup(r)-1) strains in the presence of piperine indicated that inhibition of efflux could be a possible mechanism of potentiation of mupirocin activity by piperine. The combination of piperine with mupirocin in a dermal infection model of mice showed better in vivo efficacy when compared with the commercially available formulation of 2 % mupirocin.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21680766/