Peer-reviewed veterinary case report
Radiation with chemo and piroxicam for bladder cancer in dogs
By Poirier, Valerie J et al.·Published in Journal of the American Animal Hospital Association·2004·School of Veterinary Medicine and the Comprehensive Cancer Center, United States·View original on PubMed →
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Original publication title: Piroxicam, mitoxantrone, and coarse fraction radiotherapy for the treatment of transitional cell carcinoma of the bladder in 10 dogs: a pilot study.
- Species:
- dog
Plain-English summary
Ten dogs with bladder cancer (transitional cell carcinoma) were treated with a combination of radiation therapy, chemotherapy (mitoxantrone), and an anti-inflammatory medication (piroxicam). While only two dogs showed a significant reduction in the tumor, 90% experienced improvement in their urinary symptoms, such as difficulty urinating. All dogs tolerated the treatment well, and the average survival time was about 326 days. However, this treatment did not provide better results compared to using mitoxantrone and piroxicam alone.
People also search for: dog bladder cancer treatment · transitional cell carcinoma in dogs · piroxicam for dog cancer · mitoxantrone side effects in dogs
Abstract
Ten dogs with transitional cell carcinoma (TCC) of the bladder were treated with a combination of once-weekly coarse fraction radiation therapy (six weekly fractions of 5.75 Gray [Gy]), mitoxantrone chemotherapy, and piroxicam. All dogs completed the radiation therapy protocol, and only minimal side effects were observed. Only two (22%) dogs achieved a measurable partial response; however, 90% of the dogs had amelioration of their urinary clinical signs. The median survival time for all dogs was 326 days. While this treatment protocol was well tolerated, the response rate and overall survival duration was not superior to reports using mitoxantrone and piroxicam without radiation therapy in dogs with TCC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15007049/