Peer-reviewed veterinary case report
Plaque attack by microglial PLCγ2.
- Journal:
- Immunity
- Year:
- 2023
- Authors:
- Comer, Ashley L & Hammond, Timothy R
- Affiliation:
- Sanofi · United States
Abstract
PLCγ2 is genetically linked to Alzheimer's disease (AD), but it is unclear how PLCγ2 contributes to pathology. Tsai et al. demonstrate that AD-associated PLCG2 variants bidirectionally orchestrate microglial responses to plaques and impact neural function in an AD mouse model. This positions PLCγ2 as a key microglial signaling node and shows that targeting PLCγ2 could have therapeutic benefits in AD.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37703828/