Peer-reviewed veterinary case report
Plasma amino acid changes in dogs with inflammatory bowel disease
By Yu Tamura et al.·Published in Journal of Veterinary Internal Medicine·2019·Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences Graduate School of Veterinary Medicine, Hokkaido University Sapporo Hokkaido Japan, GB·View original on DOAJ →
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Original publication title: Plasma amino acid profiles in dogs with inflammatory bowel disease
- Species:
- dog
Plain-English summary
A group of dogs with inflammatory bowel disease (IBD) had their blood tested to check for amino acids, which are important for health. The study found that dogs with IBD had lower levels of certain amino acids, like serine, compared to healthy dogs. This suggests that measuring serine levels could help veterinarians identify and monitor IBD in dogs. While more research is needed, this finding could lead to better ways to diagnose and manage this condition in our pets.
People also search for: dog inflammatory bowel disease symptoms · low serine levels in dogs · IBD treatment for dogs
Abstract
Abstract Background Lymphocytic‐plasmacytic enteritis is the common form of idiopathic inflammatory bowel disease (IBD) in dogs. In human IBD, disturbances of amino acid metabolism have been demonstrated to be involved in the pathophysiology of IBD. Therefore, plasma amino acid profile might represent a novel marker of human IBD. Objectives To determine the plasma amino acid profiles of dogs with IBD and its usefulness as a novel marker of IBD in dogs. Animals Fasting blood plasma was obtained from 10 dogs with IBD and 12 healthy dogs. Methods All IBD dogs were prospectively included in this study, and heparinized blood samples were collected. The plasma concentrations of 21 amino acids were determined using the ninhydrin method. The relationships among the plasma amino acid concentrations and plasma C‐reactive protein (CRP) concentration, canine chronic enteropathy clinical activity index (CCECAI), and overall World Small Animal Veterinary Association (WSAVA) score were investigated. Results Median concentration (nmol/mL) of methionine [46.2; range, 30.0‐59.3], proline [119.4; range, 76.7‐189.2], serine [115.1; range, 61.4‐155.9], and tryptophan [17.4; range, 11.9‐56.3]) were significantly lower than in control dogs [62.6; range, 51.0‐83.6, 199.1; range, 132.5‐376.7, 164.3; range, 124.7‐222.9, and 68.3; range, 35.7‐94.8, respectively]. A negative correlation was identified between the plasma serine concentration and CCECAI (r s = −.67, P = .03), but there were no correlations between plasma amino acid concentrations and CRP concentration or overall WSAVA score. Conclusions and Clinical Importance Plasma serine concentration might represent a novel maker of IBD in dogs.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1111/jvim.15525