Peer-reviewed veterinary case report
Antioxidant levels drop as kidney disease worsens in cats
By Krofič Žel, M et al.·Published in Journal of veterinary internal medicine·2014·Clinic for Surgery and Small Animal Medicine·View original on PubMed →
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Original publication title: Plasma and erythrocyte glutathione peroxidase activity, serum selenium concentration, and plasma total antioxidant capacity in cats with IRIS stages I-IV chronic kidney disease.
- Species:
- cat
Plain-English summary
A group of cats with chronic kidney disease (CKD) were studied to see how their blood levels of selenium and certain antioxidant enzymes compared to healthy cats. The researchers found that while the activity of one enzyme (plasma glutathione peroxidase) was higher in cats with the most severe stage of CKD, other measures like selenium levels and overall antioxidant capacity did not show significant differences between sick and healthy cats. This suggests that selenium isn't a limiting factor in these cats, and their antioxidant defenses may still be functioning well despite the disease.
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Abstract
BACKGROUND: Serum selenium concentrations and the activity of plasma glutathione peroxidase (GPx) decrease with the progression of chronic kidney disease (CKD) in human patients. Selenium is considered a limiting factor for plasma GPx synthesis. Plasma total antioxidant capacity (TAC) is decreased in CKD cats in comparison to healthy cats. HYPOTHESIS: Serum selenium concentrations and plasma and erythrocyte GPx activity in cats with CKD are lower than in healthy cats. Serum selenium concentrations, the activity of enzymes, and plasma TAC progressively decrease with the progression of kidney disease according to IRIS (International Renal Interest Society) classification. ANIMALS: Twenty-six client-owned cats in IRIS stages I-IV of CKD were compared with 19 client-owned healthy cats. METHODS: A CBC, serum biochemical profile, urinalysis, plasma and erythrocyte GPx activity, serum selenium concentration, and plasma TAC were measured in each cat. RESULTS: Cats in IRIS stage IV CKD had a significantly higher (P = .025) activity of plasma GPx (23.44 ± 6.28 U/mL) than cats in the control group (17.51 ± 3.75 U/mL). There were no significant differences in erythrocyte GPx, serum selenium concentration, and plasma TAC, either among IRIS stages I-IV CKD cats or between CKD cats and healthy cats. CONCLUSIONS AND CLINICAL IMPORTANCE: Erythrocyte GPx activity, serum selenium concentration, and plasma TAC do not change in CKD cats compared with healthy cats. Selenium is not a limiting factor in feline CKD. Increased plasma GPx activity in cats with stage IV CKD suggests induction of antioxidant defense mechanisms. Antioxidant defense systems might not be exhausted in CKD in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24341729/