Peer-reviewed veterinary case report
Oxidative stress markers rise in cats with early kidney disease
By Granick, Martin et al.·Published in Journal of Feline Medicine and Surgery·2020·Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin–Madison, Madison, WI, USA, United States·View original on Crossref →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Plasma and urinary F 2 -isoprostane markers of oxidative stress are increased in cats with early (stage 1) chronic kidney disease
- Species:
- cat
Plain-English summary
A group of cats with early chronic kidney disease (CKD) showed higher levels of certain markers of oxidative stress compared to healthy cats. Specifically, cats in stage 1 CKD had significantly elevated plasma and urinary F 2 -isoprostanes, which indicate oxidative stress. When some of these cats were switched to a special renal diet rich in omega-3 fatty acids for at least four weeks, their plasma levels of these markers decreased by 25-75%. This suggests that a renal diet may help reduce oxidative stress in cats with early CKD, potentially slowing the disease's progression.
People also search for: cat chronic kidney disease symptoms · cat renal diet omega-3 · how to manage cat kidney disease
Abstract
Objectives Oxidative stress contributes to chronic kidney disease (CKD) progression in humans and rodent models; F 2 -isoprostanes (F 2 -IsoPs) are established biomarkers of oxidative stress. Our primary aim was to evaluate plasma F 2 -IsoPs in cats with International Renal Interest Society stage 1 and 2 CKD, compared with healthy cats, and to determine whether plasma and urinary F 2 -IsoPs are equivalent biomarkers. The secondary aim was to assess whether consumption of a renal diet enriched in omega-3 fatty acids led to improvements in plasma and urinary F 2 -IsoPs. Methods Plasma and urinary F 2 -IsoPs were measured in 24 cats with stage 1 or 2 CKD, and 12 unaffected controls aged ⩾6 years. Twelve CKD cats were re-evaluated after feeding a commercial renal diet for at least 4 weeks. Results Median plasma F 2 -IsoPs were significantly higher in stage 1 CKD (96.2 pg/ml), early stage 2 CKD (83.2 pg/ml) and late stage 2 CKD (80.8 pg/ml) compared with healthy cats (22.8 pg/ml; P = 0.03−0.002). Median urinary F 2 -IsoPs were significantly higher in cats with stage 1 CKD (231.2 pg/mg) compared with healthy cats (152.5 pg/mg) or cats with late stage 2 CKD (124.8 pg/mg; P = 0.01). Plasma F 2 -IsoPs remained increased, while urinary F 2 -IsoPs fell with transition from stage 1 to stage 2 CKD. Feeding a commercial renal diet led to significant decreases in plasma F 2 -IsoPs in the small group of cats with stage 1 CKD (25−75% decrease) compared with cats with stage 2 CKD (20% decrease to 53% increase; P = 0.01). Conclusions and relevance Oxidative stress is prominent in cats with stage 1 CKD. Plasma and urinary F 2 -IsoPs are not interchangeable biomarkers in cats with stage 2 CKD. Placebo-controlled studies are indicated to evaluate dietary or pharmacologic doses of omega-3 fatty acids on redox stress and progression of renal dysfunction in cats with stage 1 CKD.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on Crossref: https://doi.org/10.1177/1098612x20969358