Peer-reviewed veterinary case report
Blood test for early detection of mitral valve disease severity
By Ebisawa, Takashi et al.·Published in Research in veterinary science·2013·Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Plasma atrial natriuretic peptide is an early diagnosis and disease severity marker of myxomatous mitral valve disease in dogs.
- Species:
- dog
Plain-English summary
A study found that dogs with myxomatous mitral valve disease (MMVD), a common heart condition, had higher levels of a substance called plasma atrial natriuretic peptide (ANP) compared to healthy dogs. This increase in ANP levels was also linked to worsening heart failure in these dogs. The researchers suggest that measuring plasma ANP could help veterinarians diagnose MMVD earlier, even before symptoms appear, and distinguish between heart enlargement and other conditions. This could lead to better management of the disease and improve outcomes for affected dogs.
People also search for: dog heart disease symptoms · myxomatous mitral valve disease treatment · high ANP levels in dogs
Abstract
The aim of this study was to retrospectively assess the clinical usefulness of plasma atrial natriuretic peptide (ANP) concentrations for determining the severity of myxomatous mitral valve disease (MMVD) in dogs. Plasma ANP levels were found to be significantly higher in dogs with MMVD compared to healthy dogs, and plasma ANP levels increased significantly in dogs with progressive heart failure. In dogs with MMVD, stepwise regression analysis revealed that the left atrium/aorta ratio and fractional shortening could be used to predict the plasma ANP concentration. These results indicated that plasma ANP rose with an increase in the volume overload of the left side of the heart. Plasma ANP discriminated cardiomegaly from non-cardiomegaly caused by asymptomatic MMVD. We conclude, therefore, that plasma ANP concentrations may be a clinically useful tool for early diagnosis of asymptomatic MMVD in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23312500/