Peer-reviewed veterinary case report
Blood markers linked to severe inflammation in dogs with babesiosis
By Kuleš, J et al.·Published in Research in veterinary science·2016·Department of Chemistry and Biochemistry·View original on PubMed →
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Original publication title: Plasma biomarkers of SIRS and MODS associated with canine babesiosis.
- Species:
- dog
Plain-English summary
A group of dogs with babesiosis, a tick-borne disease, were studied to understand how their bodies reacted to the infection. Some dogs showed signs of systemic inflammatory response syndrome (SIRS), while others had multiple organ dysfunction syndrome (MODS), which indicates a more severe condition. Researchers found specific changes in their blood that could help identify the severity of the disease. Early detection of these conditions is crucial for effective treatment. The study highlights the importance of monitoring blood markers to improve outcomes for dogs suffering from babesiosis.
People also search for: dog babesiosis symptoms · canine SIRS treatment · dog blood test results for babesiosis
Abstract
Canine babesiosis is a tick-borne disease caused by the haemoprotozoan parasites of the genus Babesia. Early detection of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) is of major importance in clinical practice for providing information about severity and outcomes of the disease and therapy. Plasma samples were taken at admission from five dogs with uncomplicated babesiosis caused by B. canis canis, five dogs with babesiosis and SIRS, five dogs with babesiosis and MODS, and five healthy dogs. After two-dimensional electrophoresis and capillary reversed - phase liquid chromatography coupled online with tandem mass spectrometry, 68 differentially expressed spots with level of significance P<0.05 were detected between groups. SIRS in babesiosis was characterised by increases in paraoxonase 1 and apoA-I, whereas MODS with decrease of complement inhibitors leading to prolonged complement activation and decrease of vitamin D binding protein due to haemolysis and activation of the coagulation cascade.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27033937/