Peer-reviewed veterinary case report
Dog with plasma cell leukemia showing aggressive cancer cells
By Dagher, Elie et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2019·Department of Biology, France·View original on PubMed →
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Original publication title: Plasma cell leukemia with plasmablastic morphology in a dog.
- Species:
- dog
Plain-English summary
A 5-year-old female Golden Retriever was brought to the vet after two weeks of not eating well, vomiting, diarrhea, being unusually tired, losing weight, and drinking and urinating more than normal. Tests showed that she had multiple enlarged organs and signs of a serious blood condition. Further examination revealed that she had a type of cancer called plasma cell leukemia, which is rare in dogs. Unfortunately, despite the diagnosis, the outcome was not favorable, and the dog had significant disease progression.
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Abstract
A 5-y-old female Golden Retriever was presented with a 2-wk history of hyporexia, vomiting, diarrhea, lethargy, weight loss, polyuria, and polydipsia. Clinical examination and ultrasonography revealed multiple organ enlargement with gallbladder and kidney nodules suggestive of disseminated neoplasia. Hematologic and biochemical analyses revealed pancytopenia, hypercalcemia, and monoclonal IgA gammopathy suspicious for a plasma cell neoplasm. Bone marrow and blood smear examination revealed neoplastic atypical cells highly suggestive of lymphoid origin. Autopsy confirmed the presence of homogeneous white masses and multifocal pale infiltrates in the spleen, kidney, small intestine, gallbladder, and urinary tract. Histologic features were consistent with a multicentric atypical plasma cell tumor. Tumor cells were negative for CD204, IBA-1, E-cadherin, CD3, CD5, CD79a, CD20, and PAX5, and positive for MUM1, consistent with plasma cell origin. The presence of > 20% of circulating blastic plasma cells was consistent with primary plasma cell leukemia with plasmablastic morphology, a disease rarely described in veterinary medicine.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31609183/