Plasma chemistry reference intervals for adult multi-drug-resistance gene deficient Collies.

Abstract

BACKGROUND: Differences in the reference intervals between dog breeds have been recognized for many years. Due to the importance of multi-drug-resistance 1-deficient (MDR1) Collies in veterinary medicine, it is important to determine whether breed-specific reference intervals are needed for this group. OBJECTIVES: The goal of this study was to establish plasma chemistry reference intervals for adult MDR1-deficient Collies. METHODS: Plasma samples collected from 110 healthy male and female adult MDR1-deficient Collies were analyzed for 21 analytes on a Beckman AU480 clinical chemistry analyzer. Reference intervals were established using a nonparametric statistical method. RESULTS: Reference intervals were established for 21 biochemical measurands in healthy adult MDR1-deficient Collies. CONCLUSION: Plasma chemistry reference intervals for MDR1-deficient Collies were clinically similar to intervals earlier created for Beagles. Intervals for male and female MDR1-deficient Collies were very similar to each other.