Peer-reviewed veterinary case report
Measuring kidney function in hyperthyroid cats
By van Hoek, I et al.·Published in Journal of veterinary internal medicine·2008·Department of Medicine & Clinical Biology of Small Animals·View original on PubMed →
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Original publication title: Plasma clearance of exogenous creatinine, exo-iohexol, and endo-iohexol in hyperthyroid cats before and after treatment with radioiodine.
- Species:
- cat
Plain-English summary
Fifteen hyperthyroid cats were tested to measure their kidney function before and after treatment with radioiodine. The study found that different methods of measuring kidney function gave significantly different results, but all methods showed a decrease in kidney function after treatment. The most important takeaway is that using the same method for testing kidney function is crucial for accurate follow-up. Testing four weeks after treatment can help determine how well the kidneys are functioning after the radioiodine therapy.
People also search for: hyperthyroid cat kidney function test · radioiodine treatment for cats · cat kidney disease symptoms
Abstract
BACKGROUND: Glomerular filtration rate (GFR) can be measured by clearance methods of different markers showing discrepancies and different reproducibility in healthy cats. Studies comparing different methods of GFR measurement in hyperthyroid cats have not yet been performed. HYPOTHESIS: Plasma clearance of exogenous creatinine (PECCT), exo-iohexol (PexICT), and endo-iohexol (PenICT) could lead to differences in GFR measurement and the need to use the same clearance method when comparing GFR before and after radioiodine treatment in hyperthyroid cats. ANIMALS: Fifteen client-owned hyperthyroid cats. METHODS: GFR was measured 1 day before and 1, 4, 12, and 24 weeks after treatment. Intravenous injection of iohexol was followed immediately by IV injection of creatinine. Plasma creatinine was measured by an enzymatic method. Plasma endo- and exo-iohexol were measured by high-performance liquid chromatography coupled to ultraviolet detection. RESULTS: Globally, the 3 GFR methods resulted in significantly different (P < .001) GFR results. GFR results among the different methods were the same (P= .999) at all time points. All 3 techniques indicated decreasing GFR after (131)I treatment. For each GFR technique, a significant decrease in GFR was observed between time point 0 and all other time points. This decrease stabilized 4 weeks after treatment, with very little decline afterward. CONCLUSION AND CLINICAL IMPORTANCE: It is mandatory to use the same GFR technique in follow-up studies. GFR testing at 4 weeks posttreatment could allow assessment of the final renal functional loss after treatment in hyperthyroid cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18498324/