Peer-reviewed veterinary case report
Lidocaine levels in dogs after 72-hour skin patch use
By Ko, Jeff et al.·Published in Journal of the American Animal Hospital Association·2007·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Plasma concentrations of lidocaine in dogs following lidocaine patch application.
- Species:
- dog
Plain-English summary
Seven dogs had 5% lidocaine patches applied to their bellies for 72 hours to see how much lidocaine would enter their bloodstream. The dogs showed detectable levels of lidocaine in their blood starting 12 hours after the patches were put on, with levels stabilizing between 24 and 48 hours. After removing the patches, the lidocaine levels dropped significantly within 60 hours, and low levels remained for an additional 6 hours. There were no serious side effects observed in any of the dogs during the study.
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Abstract
Transdermal absorption of lidocaine was determined by measuring plasma lidocaine concentrations following skin application of 5% lidocaine patches. Two lidocaine patches were placed on the ventral abdominal midline of seven dogs for 72 hours. Lidocaine was detectable in plasma 12 hours after patch application, and it reached steady-state concentrations between 24 and 48 hours. Plasma lidocaine levels decreased dramatically at 60 hours post-application. Low plasma lidocaine concentrations remained for 6 hours after patch removal. No clinically significant side effects were noted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17823477/