Peer-reviewed veterinary case report
Plasma endothelin-1 levels in normal dogs and dogs with heart disease
By Prosek, Robert et al.·Published in Journal of veterinary internal medicine·2004·Department of Veterinary Clinical Medicine, United States·View original on PubMed →
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Original publication title: Plasma endothelin-1 immunoreactivity in normal dogs and dogs with acquired heart disease.
- Species:
- dog
Plain-English summary
A study looked at plasma levels of a substance called endothelin-1 in normal dogs compared to dogs with heart disease, specifically those with dilated cardiomyopathy or degenerative valvular disease. The researchers found that dogs with congestive heart failure had significantly higher levels of endothelin-1 than normal dogs and those with heart disease but no heart failure. This suggests that measuring endothelin-1 could help veterinarians assess the severity of heart disease in dogs. Understanding these levels can guide treatment decisions for dogs suffering from heart problems.
People also search for: dog heart disease symptoms · congestive heart failure in dogs · endothelin-1 levels in dogs
Abstract
We sought to measure plasma endothelin-1 (ET-1) concentrations in normal dogs and to compare them with those measured in dogs with acquired heart disease with or without pulmonary edema. A sandwich enzyme-linked immunosorbent assay kit was validated and used to measure ET-1 immunoreactivity in plasma samples obtained from 32 normal dogs and 46 dogs with either dilated cardiomyopathy (DCM, n = 27) or degenerative valvular disease (CDVD, n = 19) with (n = 30) or without (n = 16) overt congestive heart failure (CHF). Plasma ET-1 concentrations (geometric mean, 95% confidence interval of geometric mean) were 1.17 (1.04-1.32) fmol/mL in the 32 normal control dogs, 1.25 (0.981-1.60) fmol/mL in 16 dogs with DCM (n = 9) or CDVD (n = 7) without CHF, and 2.51 (2.10-3.01) fmol/mL in 30 dogs with DCM (n = 18) and CDVD (n = 12) with CHE Plasma immunoreactivity of ET-1 was significantly higher in dogs with CHF in comparison with normal dogs (P < .001) and dogs with heart disease without CHF (P < .001). No significant difference was found between normal dogs and dogs with heart disease but without CHF (P > .05). Significant correlations were between plasma ET-I concentrations and left atrial:aortic ratio (P < .0001, r2 = .39), left ventricular internal dimension at end-diastole indexed to aortic diameter (P < .0001, r2 = .30) or body surface area (BSA) (P = .0071, r2 = .10), and left ventricular internal dimension at end-systole indexed to aortic diameter (P = .0003, r- = .17) or BSA (P = .0008, r2 = .15).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15638267/