Peer-reviewed veterinary case report
Plasma separation by centrifugation and subsequent plasma filtration: impact on survival in a pig model of sepsis.
- Journal:
- Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
- Year:
- 2012
- Authors:
- Sauer, Martin et al.
- Affiliation:
- Department of Anesthesiology and Intensive Care Medicine · Germany
Abstract
The impact on survival of a combination of plasma separation by centrifugation and subsequent plasma filtration was tested in a bacterial sepsis model in pigs. In this animal study 19 pigs were included. Groups II and III received an intravenous lethal dose of live Staphylococcus aureus over 1 h; group I received saline (non-septic control--NC). Groups I and II were treated by an extracorporeal circuit consisting of online centrifugation and subsequent plasma filtration (group II: treated group--TG) for 4 h; group III had no specific treatment (septic control, SC). The observation time was 7 days. All animals of group I (NC) and group II (TG) survived, while all animals of group III (SC) died during the observation time. Extracorporeal therapy with online centrifugation and plasma filtration significantly improved survival in a pig model of sepsis. Further studies with this approach are encouraged.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22607562/