Peer-reviewed veterinary case report
Plasmacytoid dendritic cell bactericidal activity against Burkholderia pseudomallei.
- Journal:
- Microbes and infection
- Year:
- 2015
- Authors:
- Williams, Natasha L et al.
- Affiliation:
- Australian Institute of Tropical Health and Medicine · Australia
- Species:
- rodent
Abstract
Melioidosis sepsis, caused by Burkholderia pseudomallei, is associated with high mortality due to an overwhelming inflammatory response. Plasmacytoid dendritic cells (pDC) are potent producers of type I interferons (IFN). This study investigated whether pDC and type I IFN play a role during the early stages of B. pseudomallei infection. Human and murine pDC internalised and killed B. pseudomallei as efficiently as murine conventional DC (cDC). pDC derived from B. pseudomallei-susceptible (BALB/c) mice demonstrated poor intracellular killing and increased IFN-alpha compared to pDC derived from B. pseudomallei-resistant (C57BL/6) mice. This is the first evidence of pDC bactericidal activity against B. pseudomallei infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25532693/