Peer-reviewed veterinary case report
Platelet changes in dogs with immune-related gut disease response
By Pierini, Alessio et al.·Published in The Journal of veterinary medical science·2021·Department of Veterinary Science, Italy·View original on PubMed →
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Original publication title: Platelet abnormalities and platelet-to-lymphocyte ratios in canine immunosuppressant-responsive and non-responsive enteropathy: A retrospective study in 41 dogs.
- Species:
- dog
Plain-English summary
A group of 41 dogs with chronic intestinal problems were studied to see how their platelet counts and other blood markers related to their response to treatment. Some dogs improved significantly after starting immunosuppressive therapy, while others did not respond or relapsed within a year. The researchers found that certain blood markers, like platelet volume, could help indicate how well the dogs were doing with their treatment. Overall, the study suggests that monitoring these blood markers might help vets assess treatment effectiveness in dogs with chronic enteropathy.
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Abstract
Few studies have examined platelet alterations in dogs with chronic enteropathy. Our aim was to investigate platelet count (PLT), mean platelet volume (MPV), and platelet-to-lymphocyte ratio (PLR) in dogs diagnosed with immunosuppressant-responsive enteropathy (IRE). In this retrospective study of 41 dogs, data regarding signalment, canine chronic enteropathy clinical activity index (CCECAI), endoscopic and histopathological scores, PLT, MPV, PLR, total serum protein concentrations, albumin, and iron were collected. Clinical response and relapse were assessed with the evaluation of CCECAI over time. One month after starting therapy, dogs with >25% CCECAI reduction were considered responders. During a three-month CCECAI evaluation as part of a twelve-month follow-up, a CCECAI >3 together with a ≥2 unit increase in responder dogs was considered a relapse. PLT and PLR displayed significant negative correlation with MPV. MPV was positively correlated with total protein and albumin levels and negatively correlated with CCECAI. Three dogs were classified as non-responders, and 14 relapsed within 12 months. No differences were observed in PLT, MPV, or PLR between responding/non-responding and relapsing/non-relapsing groups. PLT, MPV, and PLR correlated with total protein, albumin, and CCECAI, confirming PLT as a potential marker, and suggesting MPV as a new marker of clinical efficacy against canine IRE.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33455958/