Peer-reviewed veterinary case report
Platelet function changes in Cavalier King Charles Spaniels
By Tong, Linda J et al.·Published in American journal of veterinary research·2016·View original on PubMed →
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Original publication title: Platelet function and activation in Cavalier King Charles Spaniels with subclinical chronic valvular heart disease.
- Species:
- dog
Plain-English summary
A group of 89 Cavalier King Charles Spaniels with early signs of heart disease were tested for platelet function, which is important for blood clotting. The study found that the size of the mitral valve leak significantly affected how well the platelets functioned, indicating some dysfunction. However, the overall activation of platelets did not seem to be a problem in these dogs. This means that while there are some concerns about blood clotting in dogs with this type of heart disease, the platelets themselves were not overly activated.
People also search for: Cavalier King Charles Spaniel heart disease symptoms · dog platelet function test · mitral valve disease in dogs
Abstract
OBJECTIVE To assess platelet closure time (CT), mean platelet component (MPC) concentration, and platelet component distribution width (PCDW) in dogs with subclinical chronic valvular heart disease. ANIMALS 89 Cavalier King Charles Spaniels (CKCSs) and 39 control dogs (not CKCSs). PROCEDURES Platelet count, MPC concentration, PCDW, and Hct were measured by use of a hematology analyzer, and CT was measured by use of a platelet function analyzer. Murmur grade and echocardiographic variables (mitral valve regurgitant jet size relative to left atrial area, left atrial-to-aortic diameter ratio, and left ventricular internal dimensions) were recorded. Associations between explanatory variables (sex, age, murmur grade, echocardiographic variables, platelet count, and Hct) and outcomes (CT, MPC concentration, and PCDW) were examined by use of multivariate regression models. RESULTS A model with 5 variables best explained variation in CT (R(2), 0.74), with > 60% of the variance of CT explained by mitral valve regurgitant jet size. The model of best fit to explain variation in MPC concentration included only platelet count (R(2), 0.24). The model of best fit to explain variation in PCDW included platelet count and sex (R(2), 0.25). CONCLUSIONS AND CLINICAL RELEVANCE In this study, a significant effect of mitral valve regurgitant jet size on CT was consistent with platelet dysfunction. However, platelet activation, as assessed on the basis of the MPC concentration and PCDW, was not a feature of subclinical chronic valvular heart disease in CKCSs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27463549/