Peer-reviewed veterinary case report
Platelet function and bleeding in dogs with chronic liver disease
By Wilkinson, A et al.·Published in The Journal of small animal practice·2022·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Platelet function in dogs with chronic liver disease.
- Species:
- dog
Plain-English summary
A group of dogs with chronic liver disease underwent tests to check their blood's ability to clot and how long it took for bleeding to stop. The results showed that while these dogs had a longer time for bleeding to stop compared to healthy dogs, their overall platelet function was not significantly affected. Importantly, none of the dogs experienced bleeding complications after a liver biopsy. This suggests that dogs with chronic liver disease can safely undergo this procedure without a high risk of bleeding.
People also search for: dog liver disease symptoms · dog bleeding after biopsy · dog platelet function test
Abstract
OBJECTIVES: To assess platelet function, buccal mucosal bleeding time and plasma von Willebrand factor concentration in dogs with chronic inflammatory and/or fibrotic liver disease and to compare results with those obtained in healthy dogs. MATERIALS AND METHODS: Preliminary study including 18 dogs with chronic inflammatory and/or fibrotic liver disease undergoing liver biopsy and 18 healthy age-matched control dogs. Platelet function was assessed by measuring closure time with the PFA-100® analyser using adenosine diphosphate (ADP) as an agonist. Buccal mucosal bleeding time, closure time and plasma von Willebrand factor antigen were measured in dogs in both groups. After undergoing ultrasound-guided needle biopsy, dogs were monitored for haemorrhage to determine if there was an association of any measurement with post-biopsy bleeding. RESULTS: The closure time was not different between the liver disease group (median 76.3; range 53 to 118.5 seconds) and control group (72.8; 57 to 89.5 seconds). The buccal mucosal bleeding time was longer in the liver disease group (median 138; range 95 to 229 seconds) than the control group (103; 63 to 200 seconds). The plasma von Willebrand factor antigen concentration was not different between the liver disease group (median 203; range 109 to 351%) and control group (165.5; 63 to 246%). CLINICAL SIGNIFICANCE: In this study, dogs with chronic necroinflammatory and/or fibrotic liver disease did not have overt, clinically relevant derangements in platelet function as assessed by buccal mucosal bleeding time, closure time and von Willebrand factor analysis. In addition, none of the dogs undergoing percutaneous ultrasound-guided biopsy in the study exhibited bleeding complications post-biopsy procedure.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33900656/