Peer-reviewed veterinary case report
Injectable platelet-silk gel for dog spinal disc repair
By Chayatup, Kannika et al.·Published in Research in veterinary science·2025·Faculty of Engineering·View original on PubMed →
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Original publication title: Platelet lysate-silk fibroin injectable hydrogel as a potential biofunctional and biomechanical platform for canine intervertebral disc repair.
- Species:
- dog
Plain-English summary
A study tested a new injectable treatment for dogs with intervertebral disc degeneration (IVDD), which can cause pain and mobility issues. The treatment, called platelet lysate-silk fibroin hydrogel, was shown to help promote healing by encouraging cell growth and reducing inflammation. It also improved the mechanical stability of the spine after surgery. This innovative approach could offer a less invasive option for dogs suffering from this condition, potentially leading to better recovery outcomes.
People also search for: dog intervertebral disc disease treatment · canine back pain hydrogel · IVDD recovery options for dogs
Abstract
Intervertebral disc degeneration (IVDD) in dogs remains a major clinical problem that requires regenerative strategies capable of restoring both biological activity and mechanical stability. This study developed and evaluated an injectable platelet lysate-silk fibroin (PL-TSF) hydrogel designed as a dual-functional platform for disc repair. Biofunctional and biomechanical performances were examined using canine chondrocyte culture and nucleotomized spinal segments. The PL-TSF hydrogel provided a controlled trophic microenvironment that enhanced chondrocyte proliferation and induced early upregulation of anabolic markers (SOX9, ACAN, COL2A1), while concurrently suppressing catabolic (MMP13) and inflammatory (IL1B) responses compared with controls. In contrast, direct platelet lysate exposure triggered an acute anabolic burst that was accompanied by elevated catabolic signaling. Biomechanically, the hydrogel enhanced viscoelastic damping and partially restored axial stiffness, indicating improved load-distribution capability after discectomy. These results demonstrate the dual biofunctional and biomechanical advantages of the PL-TSF hydrogel, providing controlled trophic stimulation and transient mechanical reinforcement that address both cellular regeneration and structural stabilization in intervertebral disc repair. This highlights its potential as a minimally invasive regenerative therapy for canine IVDD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41218246/