Peer-reviewed veterinary case report
Pleuropulmonary blastoma in an equine fetus.
- Journal:
- Veterinary pathology
- Year:
- 2010
- Authors:
- Woolford, L et al.
- Affiliation:
- Royal Veterinary College · United Kingdom
- Species:
- horse
Plain-English summary
This study discusses a rare type of tumor called pleuropulmonary blastoma (PPB), which was found in an unborn horse fetus. The tumor appeared as a soft mass in the lung and had both solid and cystic (fluid-filled) parts. The researchers noted that the tumor's structure and characteristics were similar to those seen in human cases of PPB, including its location and the types of cells involved. Unfortunately, the abstract does not provide information about the outcome or treatment for this condition.
Abstract
Pleuropulmonary blastoma (PPB) is a rare biphasic tumor of children formed by mixed epithelial-and-mesenchymal elements. In this article, the authors report a pulmonary mass in an equine fetus with characteristics of PPB. A soft multicystic broad-based pleural mass was identified in the right caudal lung lobe. The mass comprised solid areas of loose mesenchyme, fenestrated by small ducts or large cystic areas lined by cuboidal epithelium. Mesenchymal elements had moderate anisocytosis, anisokaryosis, and cellular pleomorphism and were immunoreactive for vimentin. Epithelial cells lining ducts and cystic lumina were nonciliated and cuboidal with central round nuclei, minimal cellular pleomorphism, and strong immunoreactivity for cytokeratin. Pertinent characteristics in common with human PPB were the pleural-based location, the dual solid or delicate multiloculated cystic structure, the primitive mesenchymatous stroma fenestrated by well-differentiated cuboidal epithelial-lined lumina, and the occurrence during gestation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20587694/