Peer-reviewed veterinary case report
Platelet function test results in a dog with Bernard-Soulier syndrome
By Kornya, Matthew et al.·Published in Veterinary clinical pathology·2023·Department of Clinical Studies, Canada·View original on PubMed →
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Original publication title: Point-of-care platelet function testing results in a dog with Bernard-Soulier syndrome.
- Species:
- dog
Plain-English summary
A 5-year-old female European Cocker Spaniel was brought in for excessive bleeding, which led to the diagnosis of Bernard-Soulier syndrome, a rare condition affecting platelet function. The dog showed signs of prolonged bleeding time and abnormal platelet test results, indicating a problem with her blood's ability to clot. Treatment options for this condition are limited, but managing bleeding episodes and monitoring her health closely are essential. With proper care, the dog can lead a relatively normal life despite the challenges of this syndrome.
People also search for: dog bleeding problems · Cocker Spaniel platelet disorder · Bernard-Soulier syndrome in dogs
Abstract
Bernard-Soulier syndrome (BSS), also known as hemorrhagiparous thrombocytic dystrophy (OMIA 002207-9615), is a rare defect in platelet function recognized in both dogs and humans. It is caused by a deficiency in glycoprotein 1b-IX-V, the platelet surface protein which acts as a receptor for the von Willebrand factor. The characteristic features of BSS in humans and dogs include macrothrombocytes and mild-to-moderate thrombocytopenia with a bleeding tendency. This condition has previously been reported in European Cocker Spaniel dogs; however, the results of platelet function tests in these animals have not been reported. This case report describes a European Cocker Spaniel dog with spontaneously occurring Bernard-Soulier syndrome and the results of point-of-care platelet function tests, including a prolonged buccal mucosal bleeding time (>8 min), prolongation (>300 s) of PFA-200 COL/ADP, COL/EPI, and P2Y closure times, and reduced aggregation (15%-48%) with Plateletworks ADP, but with normal aggregation (92%) with Plateletworks AA. This is the first description of the results of platelet function tests in canine Bernard-Soulier syndrome.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37438861/