Peer-reviewed veterinary case report
Mixed-breed dog with sudden weakness like Leigh's disease
By Chai, Orit et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2015·Veterinary Teaching Hospital·View original on PubMed →
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Original publication title: Polioencephalomyelopathy in a mixed breed dog resembling Leigh's disease.
- Species:
- dog
Plain-English summary
A 14-month-old mixed-breed dog suddenly became unable to exercise and quickly developed weakness in all four legs. After the dog passed away, an autopsy revealed a serious brain and spinal cord condition similar to Leigh's disease, which is rare and has mostly been seen in purebred dogs. Unfortunately, due to the severity of the condition, there was no successful treatment, and the dog did not recover.
People also search for: dog exercise intolerance · mixed breed dog weakness · Leigh's disease in dogs
Abstract
A 14-month-old mixed-breed dog was presented with acute onset of exercise intolerance that quickly progressed to quadriparesis. Gross and microscopic autopsy findings indicated a type of degenerative polioencephalomyelopathy resembling subacute necrotizing encephalomyelopathy in dogs or Leigh's disease in humans. This syndrome has previously been reported only in purebred dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25565716/